EHMTI-0234. Glyceryl trinitrate provoked mast cell degranulation is secondary to the release of nitric oxide in vivo
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منابع مشابه
EVect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility
Background—Nitric oxide is a major neurotransmitter in non-adrenergic, noncholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. Aims—To study the eVect of glyceryl trinitrate, a nitric oxide donor, on gall bladder emptying in healthy subjects using a randomised,...
متن کاملIn vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: comparison with glyceryl trinitrate.
We investigated the in vitro metabolism of two (nitrooxy)butyl ester nitric oxide (NO) donor derivatives of flurbiprofen and ferulic acid, [1,1'-biphenyl]-4-acetic acid-2-fluoro-alpha-methyl-4-(nitrooxy)butyl ester (HCT 1026) and 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-(nitrooxy)butyl ester (NCX 2057), respectively, in rat blood plasma and liver subcellular fractions compared with (nit...
متن کاملEffect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility.
BACKGROUND Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS To study the effect of glyceryl trinitrate, a nitric oxide donor, on gall bladder emptying in healthy subjects using a randomi...
متن کاملThiol agents separate nitric oxide formation from vasodilation induced by glyceryl trinitrate.
The role of nitric oxide (NO) and thiol-containing compounds in glyceryl trinitrate (GTN)-induced vasodilation was investigated using the thiol-alkylating agent N-ethylmaleimide (NEM). Bovine pulmonary artery (BPA) rings were submaximally contracted with K+ and exposed to increasing concentrations of GTN after a 30-min incubation with 50 microM NEM. NEM decreased maximal relaxation (10 microM G...
متن کاملComparison with glyceryl trinitrate
The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...
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ژورنال
عنوان ژورنال: The Journal of Headache and Pain
سال: 2014
ISSN: 1129-2369,1129-2377
DOI: 10.1186/1129-2377-15-s1-f10